Molecule
8 pathways
Acetyl-CoA
Found in 8 curated pathways across 3 categories.
Interaction Network
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Active In Categories
Frequently Co-occurring Molecules
Frequently Co-occurring Enzymes
Citrate synthase×2Malate dehydrogenase×2HMG-CoA synthase×2Isocitrate dehydrogenase×1α-Ketoglutarate dehydrogenase×1Succinate dehydrogenase×1Acyl-CoA dehydrogenase×1Enoyl-CoA hydratase×1β-Hydroxyacyl-CoA dehydrogenase×1β-Ketothiolase×1Carnitine palmitoyltransferase I (CPT-I)×1Aminotransferases (ALT, AST)×1
Cross-Referenced Pathways
8 direct · 9 cross-referenced · 17 shown
Direct Involvement
8
⚡
Metabolic
Citric Acid Cycle (Krebs Cycle)
Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.
Acetyl-CoACitrateIsocitrate+6
⚡
Metabolic
β-Oxidation of Fatty Acids
Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.
Fatty acyl-CoAAcetyl-CoACarnitine+5
⚡
Metabolic
Amino Acid Catabolism
Degradation of amino acids to metabolic intermediates and ammonia.
Amino acidsα-KetoglutarateGlutamate+4
⚡
Metabolic
Ketogenesis
Hepatic production of ketone bodies from excess acetyl-CoA during fasting.
Acetyl-CoAAcetoacetyl-CoAHMG-CoA+3
⚡
Metabolic
Glyoxylate Cycle
Net conversion of acetyl-CoA to oxaloacetate, bypassing CO₂ loss steps of TCA.
Acetyl-CoAIsocitrateGlyoxylate+3
🧬
Genetic Information
Epigenetic Regulation
Heritable changes in gene expression without altering the DNA sequence.
5-MethylcytosineHistone H3/H4CpG islands+4
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Lipid Metabolism
De Novo Fatty Acid Synthesis
Cytoplasmic synthesis of palmitate from acetyl-CoA and malonyl-CoA.
Acetyl-CoAMalonyl-CoACitrate+4
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Lipid Metabolism
Cholesterol Biosynthesis (Mevalonate Pathway)
Multi-step synthesis of cholesterol from acetyl-CoA via the mevalonate pathway.
Acetyl-CoAHMG-CoAMevalonate+8
Cross-Referenced
9
— connected via related pathways