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Metabolic
Aerobic organisms
Citric Acid Cycle (Krebs Cycle)
Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.
Overview
The citric acid cycle (also known as the Krebs cycle or TCA cycle) is a series of eight enzymatic reactions that oxidize acetyl-CoA derived from carbohydrates, fats, and proteins. Each turn of the cycle produces 3 NADH, 1 FADH₂, 1 GTP, and 2 CO₂. The cycle is amphibolic, serving both catabolic and anabolic roles, providing precursors for amino acid synthesis and other biosynthetic pathways.
Cellular Location
Mitochondrial matrix
Clinical Significance
Central hub of aerobic metabolism; connects carbohydrate, lipid, and amino acid metabolism; key source of reducing equivalents for oxidative phosphorylation.