Home/Malate dehydrogenase

Enzyme

3 pathways

Malate dehydrogenase

Found in 3 curated pathways across 1 category.

Interaction Network

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Active In Categories

metabolic

Frequently Co-occurring Molecules

Malate×3 Oxaloacetate×3 Acetyl-CoA×2 Isocitrate×2 Succinate×2 Citrate×1 α-Ketoglutarate×1 Succinyl-CoA×1 Fumarate×1 Glyoxylate×1 CO₂×1 PEP×1

Frequently Co-occurring Enzymes

Citrate synthase×2 Isocitrate dehydrogenase×1 α-Ketoglutarate dehydrogenase×1 Succinate dehydrogenase×1 Isocitrate lyase×1 Malate synthase×1 Aconitase×1 PEP carboxylase×1 NADP-malic enzyme×1 RuBisCO×1

Cross-Referenced Pathways

3 direct · 6 cross-referenced · 9 shown

Direct Involvement

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Metabolic

Citric Acid Cycle (Krebs Cycle)

Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.

Acetyl-CoACitrateIsocitrate+6

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Metabolic

Glyoxylate Cycle

Net conversion of acetyl-CoA to oxaloacetate, bypassing CO₂ loss steps of TCA.

Acetyl-CoAIsocitrateGlyoxylate+3

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Metabolic

CAM Photosynthesis

Temporal separation of CO₂ fixation (night) and Calvin cycle (day) to conserve water.

CO₂PEPOxaloacetate+3

Cross-Referenced

— connected via related pathways

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Metabolic

Glycolysis

The breakdown of glucose into pyruvate, yielding ATP and NADH.

GlucoseGlucose-6-phosphateFructose-1,6-bisphosphate+4

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Metabolic

Oxidative Phosphorylation

Electron transport chain coupled to ATP synthesis via chemiosmosis.

NADHFADH₂O₂+4

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Metabolic

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

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Metabolic

Photosynthesis – Light Reactions

Capture of light energy to produce ATP and NADPH, with O₂ as a byproduct.

Chlorophyll a/bH₂OO₂+5

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Metabolic

Calvin Cycle (Light-Independent Reactions)

Fixes CO₂ into organic molecules using ATP and NADPH from light reactions.

CO₂Ribulose-1,5-bisphosphate (RuBP)3-Phosphoglycerate (3-PGA)+3

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Metabolic

Gluconeogenesis

Synthesis of glucose from non-carbohydrate precursors.

PyruvateOxaloacetatePhosphoenolpyruvate+4