α-Ketoglutarate

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

metabolic

Frequently Co-occurring Molecules

Acetyl-CoA×2 Oxaloacetate×2 Citrate×1 Isocitrate×1 Succinyl-CoA×1 Succinate×1 Fumarate×1 Malate×1 Amino acids×1 Glutamate×1 Pyruvate×1 Pyridoxal phosphate (PLP)×1

Frequently Co-occurring Enzymes

Citrate synthase×1 Isocitrate dehydrogenase×1 α-Ketoglutarate dehydrogenase×1 Succinate dehydrogenase×1 Malate dehydrogenase×1 Aminotransferases (ALT, AST)×1 Glutamate dehydrogenase×1 Phenylalanine hydroxylase×1 Branched-chain α-keto acid dehydrogenase×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

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Metabolic

Citric Acid Cycle (Krebs Cycle)

Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.

Acetyl-CoACitrateIsocitrate+6

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Metabolic

Amino Acid Catabolism

Degradation of amino acids to metabolic intermediates and ammonia.

Amino acidsα-KetoglutarateGlutamate+4

Cross-Referenced

— connected via related pathways

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Metabolic

Glycolysis

The breakdown of glucose into pyruvate, yielding ATP and NADH.

GlucoseGlucose-6-phosphateFructose-1,6-bisphosphate+4

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Metabolic

Oxidative Phosphorylation

Electron transport chain coupled to ATP synthesis via chemiosmosis.

NADHFADH₂O₂+4

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Metabolic

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

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Metabolic

Gluconeogenesis

Synthesis of glucose from non-carbohydrate precursors.

PyruvateOxaloacetatePhosphoenolpyruvate+4

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Metabolic

Urea Cycle

Converts toxic ammonia to urea for excretion.

NH₃ (ammonia)CO₂Carbamoyl phosphate+6