Home/HMG-CoA synthase

Enzyme

2 pathways

HMG-CoA synthase

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

metabolic lipid

Frequently Co-occurring Molecules

Acetyl-CoA×2 HMG-CoA×2 Acetoacetyl-CoA×1 Acetoacetate×1 β-Hydroxybutyrate×1 Acetone×1 Mevalonate×1 IPP×1 FPP×1 Squalene×1 Lanosterol×1 Cholesterol×1

Frequently Co-occurring Enzymes

Thiolase×1 HMG-CoA lyase×1 β-Hydroxybutyrate dehydrogenase×1 HMG-CoA reductase×1 Squalene synthase×1 Squalene epoxidase×1 Lanosterol synthase×1 DHCR7×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Ketogenesis

Hepatic production of ketone bodies from excess acetyl-CoA during fasting.

Acetyl-CoAAcetoacetyl-CoAHMG-CoA+3

Lipid Metabolism

Cholesterol Biosynthesis (Mevalonate Pathway)

Multi-step synthesis of cholesterol from acetyl-CoA via the mevalonate pathway.

Acetyl-CoAHMG-CoAMevalonate+8

Cross-Referenced

4

— connected via related pathways

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

Gluconeogenesis

Synthesis of glucose from non-carbohydrate precursors.

PyruvateOxaloacetatePhosphoenolpyruvate+4

Lipid Metabolism

De Novo Fatty Acid Synthesis

Cytoplasmic synthesis of palmitate from acetyl-CoA and malonyl-CoA.

Acetyl-CoAMalonyl-CoACitrate+4

Lipid Metabolism

Bile Acid Synthesis

Hepatic conversion of cholesterol to bile acids for lipid digestion and signaling.

Cholesterol7α-HydroxycholesterolCholic acid+5