Cholesterol

Found in 3 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

transport lipid

Frequently Co-occurring Molecules

ATP×1 Lipids×1 Drugs×1 Bile salts×1 Chloride ions×1 Peptides×1 Acetyl-CoA×1 HMG-CoA×1 Mevalonate×1 IPP×1 FPP×1 Squalene×1

Frequently Co-occurring Enzymes

MDR1/P-gp (ABCB1)×1 MRP1 (ABCC1)×1 BCRP (ABCG2)×1 CFTR (ABCC7)×1 ABCA1×1 TAP1/TAP2×1 HMG-CoA reductase×1 HMG-CoA synthase×1 Squalene synthase×1 Squalene epoxidase×1 Lanosterol synthase×1 DHCR7×1

Cross-Referenced Pathways

3 direct · 4 cross-referenced · 7 shown

Direct Involvement

🚪

Membrane Transport

ABC Transporter Superfamily

ATP-driven efflux pumps transporting diverse substrates across membranes.

ATPLipidsDrugs+4

🫧

Lipid Metabolism

Cholesterol Biosynthesis (Mevalonate Pathway)

Multi-step synthesis of cholesterol from acetyl-CoA via the mevalonate pathway.

Acetyl-CoAHMG-CoAMevalonate+8

🫧

Lipid Metabolism

Bile Acid Synthesis

Hepatic conversion of cholesterol to bile acids for lipid digestion and signaling.

Cholesterol7α-HydroxycholesterolCholic acid+5

Cross-Referenced

— connected via related pathways

⚡

Metabolic

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

🚪

Membrane Transport

Receptor-Mediated Endocytosis

Clathrin-coated pit internalization of receptor-ligand complexes.

ClathrinAP-2Dynamin+5

🚪

Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5

🫧

Lipid Metabolism

De Novo Fatty Acid Synthesis

Cytoplasmic synthesis of palmitate from acetyl-CoA and malonyl-CoA.

Acetyl-CoAMalonyl-CoACitrate+4