Home/TAP1/TAP2

Molecule & Enzyme

2 pathways

TAP1/TAP2

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

immune transport

Frequently Co-occurring Molecules

Peptides×2 MHC class I×1 MHC class II×1 β2-microglobulin×1 Tapasin×1 Invariant chain (Ii)×1 HLA-DM×1 CLIP×1 ATP×1 Lipids×1 Drugs×1 Bile salts×1

Frequently Co-occurring Enzymes

Proteasome (immunoproteasome)×1 Cathepsins (B, D, L, S)×1 ERAP1/2 (aminopeptidases)×1 TAP (ABC transporter)×1 MDR1/P-gp (ABCB1)×1 MRP1 (ABCC1)×1 BCRP (ABCG2)×1 CFTR (ABCC7)×1 ABCA1×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Immune Response

Antigen Processing & Presentation

MHC-mediated display of peptide antigens to T cells.

MHC class IMHC class IIβ2-microglobulin+6

Membrane Transport

ABC Transporter Superfamily

ATP-driven efflux pumps transporting diverse substrates across membranes.

ATPLipidsDrugs+4

Cross-Referenced

4

— connected via related pathways

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7

Membrane Transport

Receptor-Mediated Endocytosis

Clathrin-coated pit internalization of receptor-ligand complexes.

ClathrinAP-2Dynamin+5

Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5