Home/ERAP1/2 (aminopeptidases)

Enzyme

1 pathway

ERAP1/2 (aminopeptidases)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

MHC class I×1 MHC class II×1 β2-microglobulin×1 Peptides×1 TAP1/TAP2×1 Tapasin×1 Invariant chain (Ii)×1 HLA-DM×1 CLIP×1

Frequently Co-occurring Enzymes

Proteasome (immunoproteasome)×1 Cathepsins (B, D, L, S)×1 TAP (ABC transporter)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Immune Response

Antigen Processing & Presentation

MHC-mediated display of peptide antigens to T cells.

MHC class IMHC class IIβ2-microglobulin+6

Cross-Referenced

2

— connected via related pathways

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7