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Immune Response Pathways
Innate and adaptive immunity
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Immune Response
Toll-Like Receptor (TLR) Signaling
Pattern recognition receptors activating innate immune responses.
TLR1-10LPSCpG DNA+6
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Immune Response
T Cell Receptor Signaling
Antigen-specific activation of T lymphocytes via TCR-MHC interaction.
TCR-CD3 complexMHC-peptideCD4/CD8+7
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Immune Response
Complement System
Cascade of plasma proteins enhancing pathogen clearance and inflammation.
C1qC3C3a/C3b+6
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Immune Response
Inflammasome Pathway
Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.
NLRP3ASCPro-caspase-1+6
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Immune Response
Type I Interferon Response
Antiviral defense system activating hundreds of interferon-stimulated genes.
IFN-αIFN-βIFNAR1/2+7
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Immune Response
B Cell Receptor Signaling
Antigen-specific activation of B lymphocytes for antibody production.
BCR (membrane Ig)Igα/Igβ (CD79a/b)Lyn+8
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Immune Response
Antigen Processing & Presentation
MHC-mediated display of peptide antigens to T cells.
MHC class IMHC class IIβ2-microglobulin+6
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Immune Response
cGAS-STING Pathway
Cytosolic DNA sensing pathway activating innate immune defense.
dsDNAcGAS2'3'-cGAMP+5
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Immune Response
Natural Killer Cell Activation
Innate lymphocyte killing of virus-infected and tumor cells via receptor balance.
NKG2DNKp30/46CD16 (FcγRIII)+6
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Immune Response
T Helper Cell Differentiation
Polarization of naive CD4+ T cells into specialized effector subsets.
IL-12IFN-γIL-4+10