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Membrane Transport
Universal
ABC Transporter Superfamily
ATP-driven efflux pumps transporting diverse substrates across membranes.
Overview
ABC transporters use ATP hydrolysis to transport substrates against concentration gradient. 48 human genes in 7 subfamilies (ABCA-ABCG). Includes CFTR, MDR1/P-glycoprotein, ABCA1, and ABCG2/BCRP.
Cellular Location
Plasma membrane, ER, mitochondria, peroxisomes
Clinical Significance
CFTR mutations cause cystic fibrosis; MDR1 causes multidrug resistance in cancer; ABCA1 deficiency causes Tangier disease.