Home/HMG-CoA reductase

Enzyme

1 pathway

HMG-CoA reductase

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Acetyl-CoA×1 HMG-CoA×1 Mevalonate×1 IPP×1 FPP×1 Squalene×1 Lanosterol×1 Cholesterol×1 SREBP-2×1 SCAP×1 Insig×1

Frequently Co-occurring Enzymes

HMG-CoA synthase×1 Squalene synthase×1 Squalene epoxidase×1 Lanosterol synthase×1 DHCR7×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Lipid Metabolism

Cholesterol Biosynthesis (Mevalonate Pathway)

Multi-step synthesis of cholesterol from acetyl-CoA via the mevalonate pathway.

Acetyl-CoAHMG-CoAMevalonate+8

Cross-Referenced

2

— connected via related pathways

Lipid Metabolism

De Novo Fatty Acid Synthesis

Cytoplasmic synthesis of palmitate from acetyl-CoA and malonyl-CoA.

Acetyl-CoAMalonyl-CoACitrate+4

Lipid Metabolism

Bile Acid Synthesis

Hepatic conversion of cholesterol to bile acids for lipid digestion and signaling.

Cholesterol7α-HydroxycholesterolCholic acid+5