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Genetic Information
Universal
Transcription
Synthesis of RNA from a DNA template by RNA polymerase.
Overview
Transcription is the process by which the information in a strand of DNA is copied into a new molecule of messenger RNA (mRNA). In eukaryotes, RNA Polymerase II transcribes protein-coding genes after the assembly of a pre-initiation complex at the promoter. The process involves initiation, elongation, and termination phases, followed by post-transcriptional modifications including 5' capping, 3' polyadenylation, and splicing.
Cellular Location
Nucleus (eukaryotes)
Clinical Significance
First step in gene expression; regulated by transcription factors, enhancers, and epigenetic modifications; target of α-amanitin and rifampicin.