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Genetic Information
Universal
DNA Repair Pathways
Multiple mechanisms to detect and correct DNA damage.
Overview
Cells employ several DNA repair mechanisms: Base Excision Repair (BER) for small base modifications, Nucleotide Excision Repair (NER) for bulky adducts and UV damage, Mismatch Repair (MMR) for replication errors, Homologous Recombination (HR) and Non-Homologous End Joining (NHEJ) for double-strand breaks.
Cellular Location
Nucleus
Clinical Significance
Maintains genomic integrity; defects cause cancer predisposition syndromes; PARP inhibitors exploit HR deficiency in cancer therapy.