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Enzyme

1 pathway

PARP1

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Damaged DNA×1 PCNA×1 RPA×1 RAD51×1 Ku70/Ku80×1 BRCA1/BRCA2×1 γH2AX×1

Frequently Co-occurring Enzymes

DNA glycosylases (BER)×1 XPC/XPA (NER)×1 MSH2/MLH1 (MMR)×1 RAD51 (HR)×1 DNA-PKcs (NHEJ)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Genetic Information

DNA Repair Pathways

Multiple mechanisms to detect and correct DNA damage.

Damaged DNAPCNARPA+4

Cross-Referenced

2

— connected via related pathways

Genetic Information

DNA Replication

Semi-conservative duplication of the genome before cell division.

dsDNA templatedNTPsRNA primers+3

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.