Home/γH2AX

Molecule

2 pathways

γH2AX

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

genetic cell-cycle

Frequently Co-occurring Molecules

Damaged DNA×1 PCNA×1 RPA×1 RAD51×1 Ku70/Ku80×1 BRCA1/BRCA2×1 p53×1 p21×1 ATM×1 ATR×1 Chk1×1 Chk2×1

Frequently Co-occurring Enzymes

DNA glycosylases (BER)×1 XPC/XPA (NER)×1 MSH2/MLH1 (MMR)×1 RAD51 (HR)×1 DNA-PKcs (NHEJ)×1 PARP1×1 ATM kinase×1 ATR kinase×1 Chk1×1 Chk2×1 Wee1×1 Cdc25 phosphatases×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Genetic Information

DNA Repair Pathways

Multiple mechanisms to detect and correct DNA damage.

Damaged DNAPCNARPA+4

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.

Cross-Referenced

3

— connected via related pathways

Genetic Information

DNA Replication

Semi-conservative duplication of the genome before cell division.

dsDNA templatedNTPsRNA primers+3

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.