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Cell Cycle
Eukaryotes
Cell Cycle Regulation
Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.
Overview
The eukaryotic cell cycle is controlled by cyclin-dependent kinases (CDKs) that are activated by cyclins at specific phases. Cyclin D-CDK4/6 drives G1 progression, Cyclin E-CDK2 triggers S phase entry, Cyclin A-CDK2 controls S phase and G2, and Cyclin B-CDK1 drives mitotic entry. CDK inhibitors (p21, p27, p16) and the retinoblastoma protein (Rb) provide additional regulation.
Cellular Location
Nucleus, cytoplasm
Clinical Significance
Dysregulation is a hallmark of cancer; CDK4/6 inhibitors (palbociclib, ribociclib) are major cancer therapeutics.