Home/p16INK4a

Molecule

2 pathways

p16INK4a

Found in 2 curated pathways across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

Rb×2 p53×2 p21×2 Cyclin D/E/A/B×1 CDK1/2/4/6×1 E2F×1 p27×1 Telomeres×1 SA-β-galactosidase×1 SASP factors (IL-6, IL-8, MMP-3)×1

Frequently Co-occurring Enzymes

CDK4/6×2 CDK2×1 CDK1×1 APC/C (ubiquitin ligase)×1 SCF (ubiquitin ligase)×1 ATM/ATR kinases×1 ATM/ATR×1 Telomerase (absent)×1 mTOR×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

Cellular Senescence

Permanent cell cycle arrest in response to stress or telomere shortening.

p53p21p16INK4a+4

Cross-Referenced

4

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Genetic Information

DNA Replication

Semi-conservative duplication of the genome before cell division.

dsDNA templatedNTPsRNA primers+3

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.