Home/ATM/ATR

Enzyme

1 pathway

ATM/ATR

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

p53×1 p21×1 p16INK4a×1 Rb×1 Telomeres×1 SA-β-galactosidase×1 SASP factors (IL-6, IL-8, MMP-3)×1

Frequently Co-occurring Enzymes

CDK4/6×1 Telomerase (absent)×1 mTOR×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Cellular Senescence

Permanent cell cycle arrest in response to stress or telomere shortening.

p53p21p16INK4a+4

Cross-Referenced

3

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.