Home/ATR

Molecule

1 pathway

ATR

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

p53×1 p21×1 ATM×1 Chk1×1 Chk2×1 γH2AX×1 Mad2×1 BubR1×1 14-3-3σ×1

Frequently Co-occurring Enzymes

ATM kinase×1 ATR kinase×1 Chk1×1 Chk2×1 Wee1×1 Cdc25 phosphatases×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.

Cross-Referenced

3

— connected via related pathways

Genetic Information

DNA Repair Pathways

Multiple mechanisms to detect and correct DNA damage.

Damaged DNAPCNARPA+4

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.