Home/IFN-α
Molecule
4 pathways

IFN-α

Found in 4 curated pathways across 1 category.

Interaction Network

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Active In Categories

immune

Frequently Co-occurring Molecules

IFN-β×2IFNAR1/2×2STAT1/STAT2×2IRF9×2ISGF3×2RIG-I×2MDA5×2cGAS×2STING×2IFN-γ×2NKG2D×1NKp30/46×1

Frequently Co-occurring Enzymes

TYK2×3cGAS×2TBK1×2JAK1×2PKR×2RNase L×2Granzyme B (serine protease)×1Perforin (pore-forming)×1Vav1×1PI3K×1PLCγ2×1JAK1/2/3×1

Cross-Referenced Pathways

4 direct · 7 cross-referenced · 11 shown

Cross-Referenced

7
— connected via related pathways
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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2
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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4
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Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6
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Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7
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Immune Response

Antigen Processing & Presentation

MHC-mediated display of peptide antigens to T cells.

MHC class IMHC class IIβ2-microglobulin+6
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Cell Death

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

BAXBAKBCL-2+7
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Developmental

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5