Home/PLCγ2
Molecule & Enzyme
3 pathways

PLCγ2

Found in 3 curated pathways across 1 category.

Interaction Network

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Active In Categories

immune

Frequently Co-occurring Molecules

BCR (membrane Ig)×2Igα/Igβ (CD79a/b)×2Lyn×2Syk×2BTK×2BLNK×2DAG×2IP3×2NFAT×2NF-κB×2NKG2D×1NKp30/46×1

Frequently Co-occurring Enzymes

Lyn kinase×2Syk kinase×2BTK×2PI3Kδ×2PKCβ×2Granzyme B (serine protease)×1Perforin (pore-forming)×1Vav1×1PI3K×1

Cross-Referenced Pathways

3 direct · 6 cross-referenced · 9 shown

Cross-Referenced

6
— connected via related pathways
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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4
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Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7
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Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7
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Immune Response

Antigen Processing & Presentation

MHC-mediated display of peptide antigens to T cells.

MHC class IMHC class IIβ2-microglobulin+6
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Cell Death

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

BAXBAKBCL-2+7