DAG

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

signaling immune

Frequently Co-occurring Molecules

IP3×2 GPCRs×1 Gαs/Gαi/Gαq/Gα12×1 Gβγ×1 cAMP×1 Ca²⁺×1 β-Arrestin×1 GRKs×1 BCR (membrane Ig)×1 Igα/Igβ (CD79a/b)×1 Lyn×1 Syk×1

Frequently Co-occurring Enzymes

Adenylyl cyclase×1 PLCβ×1 PKA×1 PKC×1 GRK kinases×1 Phosphodiesterases (PDEs)×1 Lyn kinase×1 Syk kinase×1 BTK×1 PLCγ2×1 PI3Kδ×1 PKCβ×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

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Immune Response

B Cell Receptor Signaling

Antigen-specific activation of B lymphocytes for antibody production.

BCR (membrane Ig)Igα/Igβ (CD79a/b)Lyn+8

Cross-Referenced

— connected via related pathways

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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

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Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7