Home/Signal Transduction
📡

Signal Transduction Pathways

Cell communication and response cascades

📡
Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3
📡
Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
📡
Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5
📡
Signal Transduction

Notch Signaling Pathway

Juxtacrine signaling controlling cell fate decisions via proteolytic receptor activation.

Notch 1-4 receptorsDelta-like ligands (DLL1, DLL3, DLL4)Jagged ligands (JAG1, JAG2)+3
📡
Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2
📡
Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4
📡
Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6
📡
Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6
📡
Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4
📡
Signal Transduction

AMPK Pathway

Cellular energy sensor activating catabolic and inhibiting anabolic pathways.

AMPADPATP+5
📡
Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3
📡
Signal Transduction

Hippo Signaling Pathway

Organ size control pathway regulating cell proliferation and apoptosis.

MST1/2 (STK3/4)SAV1LATS1/2+5
📡
Signal Transduction

VEGF Signaling (Angiogenesis)

Vascular endothelial growth factor driving new blood vessel formation.

VEGF-A/B/C/DVEGFR-1/2/3Neuropilin+3