Home/NFAT

Molecule

2 pathways

NFAT

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

TCR-CD3 complex×1 MHC-peptide×1 CD4/CD8×1 Lck×1 ZAP-70×1 LAT×1 SLP-76×1 AP-1×1 IL-2×1 BCR (membrane Ig)×1 Igα/Igβ (CD79a/b)×1 Lyn×1

Frequently Co-occurring Enzymes

Lck (Src kinase)×1 ZAP-70×1 PLCγ1×1 Calcineurin×1 PKCθ×1 PI3K×1 Lyn kinase×1 Syk kinase×1 BTK×1 PLCγ2×1 PI3Kδ×1 PKCβ×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7

Immune Response

B Cell Receptor Signaling

Antigen-specific activation of B lymphocytes for antibody production.

BCR (membrane Ig)Igα/Igβ (CD79a/b)Lyn+8

Cross-Referenced

3

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4