Home/Calcineurin
Molecule & Enzyme
4 pathways

Calcineurin

Found in 4 curated pathways across 3 categories.

Interaction Network

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Active In Categories

signalingimmuneneuronal

Frequently Co-occurring Molecules

Ca²⁺×3Calmodulin×1IP3×1cADPR×1NAADP×1STIM1×1Orai1×1TCR-CD3 complex×1MHC-peptide×1CD4/CD8×1Lck×1ZAP-70×1

Frequently Co-occurring Enzymes

CaMKII×3PKC×2SERCA (Ca²⁺-ATPase)×1IP3 receptor×1Ryanodine receptor×1PMCA×1Lck (Src kinase)×1ZAP-70×1PLCγ1×1PKCθ×1PI3K×1Glutaminase×1

Cross-Referenced Pathways

4 direct · 7 cross-referenced · 11 shown

Cross-Referenced

7
— connected via related pathways
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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3
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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4
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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6
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Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3
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Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5
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Neuronal

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6