Home/CaMKII
Molecule & Enzyme
5 pathways

CaMKII

Found in 5 curated pathways across 3 categories.

Interaction Network

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Active In Categories

signalingneuronalmuscle

Frequently Co-occurring Molecules

Ca²⁺×4NMDA receptor×2AMPA receptor×2CREB×2BDNF×2Arc×2PSD-95×2Calcineurin×2Calmodulin×1IP3×1cADPR×1NAADP×1

Frequently Co-occurring Enzymes

PKC×3PKA×3Calcineurin×2Calcineurin (PP2B)×2PP1×2CREB kinases×2SERCA (Ca²⁺-ATPase)×1IP3 receptor×1Ryanodine receptor×1PMCA×1Glutaminase×1Glutamine synthetase (astrocytes)×1

Cross-Referenced Pathways

5 direct · 4 cross-referenced · 9 shown

Direct Involvement

5
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Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4
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Neuronal

Glutamate Signaling

Excitatory neurotransmission via ionotropic and metabotropic glutamate receptors.

GlutamateAMPA receptorsNMDA receptors+6
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Neuronal

Long-Term Potentiation / Depression (LTP/LTD)

Activity-dependent strengthening or weakening of synaptic connections.

NMDA receptorAMPA receptorCa²⁺+6
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Neuronal

Long-Term Potentiation / Depression (LTP/LTD)

Activity-dependent strengthening or weakening of synaptic connections.

NMDA receptorAMPA receptorCa²⁺+6
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Muscle & Cytoskeleton

Cardiac Conduction System

Electrical conduction system coordinating rhythmic heart contraction.

HCN channels (If)L-type Ca²⁺ channels (Cav1.2)Nav1.5 (SCN5A)+4