Home/SERCA (Ca²⁺-ATPase)

Enzyme

2 pathways

SERCA (Ca²⁺-ATPase)

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

signaling muscle

Frequently Co-occurring Molecules

Ca²⁺×2 Calmodulin×1 IP3×1 cADPR×1 NAADP×1 STIM1×1 Orai1×1 Actin (thin filament)×1 Myosin II (thick filament)×1 Tropomyosin×1 Troponin (TnC, TnI, TnT)×1 ATP×1

Frequently Co-occurring Enzymes

IP3 receptor×1 Ryanodine receptor×1 CaMKII×1 Calcineurin×1 PMCA×1 Myosin ATPase×1 Creatine kinase×1 MLCK (smooth muscle)×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

Muscle & Cytoskeleton

Muscle Contraction (Excitation-Contraction Coupling)

Calcium-dependent actin-myosin sliding mechanism generating muscle force.

Actin (thin filament)Myosin II (thick filament)Tropomyosin+6

Cross-Referenced

3

— connected via related pathways

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6