CREB

Found in 3 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

signaling neuronal

Frequently Co-occurring Molecules

cAMP×2 ATP×2 PKA regulatory subunits×2 PKA catalytic subunits×2 EPAC×2 NMDA receptor×1 AMPA receptor×1 Ca²⁺×1 CaMKII×1 BDNF×1 Arc×1 PSD-95×1

Frequently Co-occurring Enzymes

PKA×3 Adenylyl cyclase×2 Phosphodiesterases (PDE3/4)×2 CaMKII×1 Calcineurin (PP2B)×1 PKC×1 PP1×1 CREB kinases×1

Cross-Referenced Pathways

3 direct · 4 cross-referenced · 7 shown

Direct Involvement

📡

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

📡

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

🧠

Neuronal

Long-Term Potentiation / Depression (LTP/LTD)

Activity-dependent strengthening or weakening of synaptic connections.

NMDA receptorAMPA receptorCa²⁺+6

Cross-Referenced

— connected via related pathways

⚡

Metabolic

Glycogen Metabolism

Synthesis and degradation of glycogen for glucose storage and release.

GlycogenUDP-glucoseGlucose-1-phosphate+5

📡

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

📡

Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

🧠

Neuronal

Glutamate Signaling

Excitatory neurotransmission via ionotropic and metabotropic glutamate receptors.

GlutamateAMPA receptorsNMDA receptors+6