cGAS

Found in 4 curated pathways across 1 category.

Interaction Network

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Active In Categories

immune

Frequently Co-occurring Molecules

STING×4 IFN-α×2 IFN-β×2 IFNAR1/2×2 STAT1/STAT2×2 IRF9×2 ISGF3×2 RIG-I×2 MDA5×2 dsDNA×2 2'3'-cGAMP×2 TBK1×2

Frequently Co-occurring Enzymes

TBK1×2 JAK1×2 TYK2×2 PKR×2 RNase L×2 TBK1 kinase×2 IKKε×2 ENPP1 (cGAMP hydrolase)×2

Cross-Referenced Pathways

4 direct · 3 cross-referenced · 7 shown

Direct Involvement

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Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7

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Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7

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Immune Response

cGAS-STING Pathway

Cytosolic DNA sensing pathway activating innate immune defense.

dsDNAcGAS2'3'-cGAMP+5

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Immune Response

cGAS-STING Pathway

Cytosolic DNA sensing pathway activating innate immune defense.

dsDNAcGAS2'3'-cGAMP+5

Cross-Referenced

— connected via related pathways

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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6