IKKα/β/γ

Found in 4 curated pathways across 2 categories.

Interaction Network

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Active In Categories

signaling immune

Frequently Co-occurring Molecules

NF-κB (p65/RelA, p50)×3 IκBα×3 TNF×3 IL-1×3 TRAF proteins×3 Ubiquitin chains×3 dsDNA×1 cGAS×1 2'3'-cGAMP×1 STING×1 TBK1×1 IRF3×1

Frequently Co-occurring Enzymes

IKKα×3 IKKβ×3 IKKγ/NEMO×3 A20 (deubiquitinase)×3 cGAS×1 TBK1 kinase×1 IKKε×1 ENPP1 (cGAMP hydrolase)×1

Cross-Referenced Pathways

4 direct · 3 cross-referenced · 7 shown

Direct Involvement

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Immune Response

cGAS-STING Pathway

Cytosolic DNA sensing pathway activating innate immune defense.

dsDNAcGAS2'3'-cGAMP+5

Cross-Referenced

— connected via related pathways

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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

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Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

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Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7