Home/TNF

Molecule

1 pathway

TNF

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

NF-κB (p65/RelA, p50)×1 IκBα×1 IKKα/β/γ×1 IL-1×1 TRAF proteins×1 Ubiquitin chains×1

Frequently Co-occurring Enzymes

IKKα×1 IKKβ×1 IKKγ/NEMO×1 A20 (deubiquitinase)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Cross-Referenced

2

— connected via related pathways

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6