IL-1

Found in 3 curated pathways across 3 categories.

Interaction Network

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Active In Categories

signaling immune apoptosis

Frequently Co-occurring Molecules

IL-1β×2 IL-18×2 Gasdermin D×2 NF-κB (p65/RelA, p50)×1 IκBα×1 IKKα/β/γ×1 TNF×1 TRAF proteins×1 Ubiquitin chains×1 NLRP3×1 ASC×1 Pro-caspase-1×1

Frequently Co-occurring Enzymes

IKKα×1 IKKβ×1 IKKγ/NEMO×1 A20 (deubiquitinase)×1 Caspase-1×1 NEK7×1 Gasdermin D (pore-forming)×1 Caspase-1 (canonical)×1 Caspase-4/5/11 (non-canonical)×1 Caspase-3 (cleaves GSDME)×1 NLRP3×1

Cross-Referenced Pathways

3 direct · 4 cross-referenced · 7 shown

Direct Involvement

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

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Cell Death

Pyroptosis

Inflammatory cell death mediated by gasdermin pore formation.

Gasdermin DGasdermin EIL-1β+4

Cross-Referenced

— connected via related pathways

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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

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Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

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Cell Death

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

BAXBAKBCL-2+7

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Cell Death

Necroptosis

Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.

RIPK1RIPK3MLKL+3