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Cell Death Pathways
Apoptosis, necrosis, autophagy, and ferroptosis
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Cell Death
Intrinsic Apoptosis (Mitochondrial)
Cell death triggered by internal stress via mitochondrial cytochrome c release.
BAXBAKBCL-2+7
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Cell Death
Extrinsic Apoptosis (Death Receptor)
Cell death initiated by death ligand-receptor interactions at the cell surface.
FasL/FasTNF/TNFR1TRAIL/DR4/DR5+4
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Cell Death
Autophagy
Self-digestion pathway recycling cellular components via lysosomal degradation.
ULK1 complexBeclin-1VPS34+6
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Cell Death
Necroptosis
Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.
RIPK1RIPK3MLKL+3
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Cell Death
Ferroptosis
Iron-dependent regulated cell death driven by lipid peroxidation.
Fe²⁺/Fe³⁺Lipid peroxides (PLOOH)Glutathione (GSH)+4
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Cell Death
Pyroptosis
Inflammatory cell death mediated by gasdermin pore formation.
Gasdermin DGasdermin EIL-1β+4