Home/NLRP3

Molecule & Enzyme

2 pathways

NLRP3

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

immune apoptosis

Frequently Co-occurring Molecules

IL-1β×2 IL-18×2 Gasdermin D×2 ASC×1 Pro-caspase-1×1 K+ efflux×1 ROS×1 mtDNA×1 Gasdermin E×1 HMGB1×1 LPS (cytoplasmic)×1 Inflammasome components×1

Frequently Co-occurring Enzymes

Caspase-1×1 NEK7×1 Gasdermin D (pore-forming)×1 Caspase-1 (canonical)×1 Caspase-4/5/11 (non-canonical)×1 Caspase-3 (cleaves GSDME)×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

Pyroptosis

Inflammatory cell death mediated by gasdermin pore formation.

Gasdermin DGasdermin EIL-1β+4

Cross-Referenced

4

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

Necroptosis

Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.

RIPK1RIPK3MLKL+3