Home/HMGB1

Molecule

1 pathway

HMGB1

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

Gasdermin D×1 Gasdermin E×1 IL-1β×1 IL-18×1 LPS (cytoplasmic)×1 Inflammasome components×1

Frequently Co-occurring Enzymes

Caspase-1 (canonical)×1 Caspase-4/5/11 (non-canonical)×1 Caspase-3 (cleaves GSDME)×1 NLRP3×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Pyroptosis

Inflammatory cell death mediated by gasdermin pore formation.

Gasdermin DGasdermin EIL-1β+4

Cross-Referenced

3

— connected via related pathways

Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

Necroptosis

Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.

RIPK1RIPK3MLKL+3