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Molecule

1 pathway

mtDNA

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

NLRP3×1 ASC×1 Pro-caspase-1×1 IL-1β×1 IL-18×1 Gasdermin D×1 K+ efflux×1 ROS×1

Frequently Co-occurring Enzymes

Caspase-1×1 NEK7×1 Gasdermin D (pore-forming)×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

Cross-Referenced

3

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.