Home/ENPP1 (cGAMP hydrolase)

Enzyme

1 pathway

ENPP1 (cGAMP hydrolase)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

dsDNA×1 cGAS×1 2'3'-cGAMP×1 STING×1 TBK1×1 IRF3×1 Type I IFN×1 NF-κB×1

Frequently Co-occurring Enzymes

cGAS×1 TBK1 kinase×1 IKKε×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Immune Response

cGAS-STING Pathway

Cytosolic DNA sensing pathway activating innate immune defense.

dsDNAcGAS2'3'-cGAMP+5

Cross-Referenced

3

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7