Home/STING

Molecule

2 pathways

STING

Found in 2 curated pathways across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

cGAS×2 IFN-α×1 IFN-β×1 IFNAR1/2×1 STAT1/STAT2×1 IRF9×1 ISGF3×1 RIG-I×1 MDA5×1 dsDNA×1 2'3'-cGAMP×1 TBK1×1

Frequently Co-occurring Enzymes

cGAS×2 TBK1×1 JAK1×1 TYK2×1 PKR×1 RNase L×1 TBK1 kinase×1 IKKε×1 ENPP1 (cGAMP hydrolase)×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7

Immune Response

cGAS-STING Pathway

Cytosolic DNA sensing pathway activating innate immune defense.

dsDNAcGAS2'3'-cGAMP+5

Cross-Referenced

3

— connected via related pathways

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6