TYK2

Found in 3 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

signaling immune

Frequently Co-occurring Molecules

Cytokines (IL-6, IFN, EPO)×1 JAK1/2/3, TYK2×1 STAT1-6×1 SOCS1-7×1 PIAS×1 IFN-α×1 IFN-β×1 IFNAR1/2×1 STAT1/STAT2×1 IRF9×1 ISGF3×1 RIG-I×1

Frequently Co-occurring Enzymes

JAK1×2 JAK2×1 JAK3×1 cGAS×1 TBK1×1 PKR×1 RNase L×1 JAK1/2/3×1 STAT1/3/4/5/6×1

Cross-Referenced Pathways

3 direct · 5 cross-referenced · 8 shown

Direct Involvement

📡

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

🛡️

Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7

🛡️

Immune Response

T Helper Cell Differentiation

Polarization of naive CD4+ T cells into specialized effector subsets.

IL-12IFN-γIL-4+10

Cross-Referenced

— connected via related pathways

📡

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

📡

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

🛡️

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6

🛡️

Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7

🌱

Developmental

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5