Home/JAK2

Molecule & Enzyme

4 pathways

JAK2

Found in 4 curated pathways across 2 categories.

Interaction Network

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Active In Categories

signaling endocrine

Frequently Co-occurring Molecules

Leptin×2 LepRb×2 STAT3×2 SOCS3×2 PTP1B×2 POMC×2 AgRP×2 NPY×2 α-MSH×2 MC4R×2 Cytokines (IL-6, IFN, EPO)×1 JAK1/2/3, TYK2×1

Frequently Co-occurring Enzymes

PI3K×3 STAT3×2 AMPK (inhibited by leptin)×2 SHP2×2 JAK1×1 JAK3×1 TYK2×1 STAT5a/5b×1 IGF-1R kinase×1 AKT×1

Cross-Referenced Pathways

4 direct · 5 cross-referenced · 9 shown

Direct Involvement

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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

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Endocrine

Growth Hormone / IGF-1 Axis

GH-driven somatic growth and metabolism via hepatic IGF-1 production.

GHRHSomatostatinGhrelin+6

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Endocrine

Leptin Signaling

Adipocyte hormone signaling to the hypothalamus regulating energy balance.

LeptinLepRbJAK2+8

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Endocrine

Leptin Signaling

Adipocyte hormone signaling to the hypothalamus regulating energy balance.

LeptinLepRbJAK2+8

Cross-Referenced

— connected via related pathways

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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

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Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

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Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6

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Signal Transduction

AMPK Pathway

Cellular energy sensor activating catabolic and inhibiting anabolic pathways.

AMPADPATP+5