AKT

Found in 4 curated pathways across 2 categories.

Interaction Network

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Active In Categories

signaling endocrine

Frequently Co-occurring Molecules

Insulin×2 Insulin receptor×2 IRS-1/2×2 PI3K×2 GLUT4×2 GSK-3β×2 mTOR×2 FOXO1×2 PIP2×1 PIP3×1 AKT/PKB×1 mTORC1×1

Frequently Co-occurring Enzymes

PI3K×4 mTOR×3 Insulin receptor kinase×2 GSK-3β×2 PTP1B (negative regulator)×2 PTEN×1 PDK1×1 S6 kinase×1 JAK2×1 STAT5a/5b×1 IGF-1R kinase×1

Cross-Referenced Pathways

4 direct · 3 cross-referenced · 7 shown

Direct Involvement

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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

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Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6

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Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6

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Endocrine

Growth Hormone / IGF-1 Axis

GH-driven somatic growth and metabolism via hepatic IGF-1 production.

GHRHSomatostatinGhrelin+6

Cross-Referenced

— connected via related pathways

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Metabolic

Glycogen Metabolism

Synthesis and degradation of glycogen for glucose storage and release.

GlycogenUDP-glucoseGlucose-1-phosphate+5

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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2