Home/Insulin

Molecule

2 pathways

Insulin

Found in 2 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

metabolic signaling

Frequently Co-occurring Molecules

Glycogen×1 UDP-glucose×1 Glucose-1-phosphate×1 Glucose-6-phosphate×1 cAMP×1 Glucagon×1 Epinephrine×1 Insulin receptor×1 IRS-1/2×1 PI3K×1 AKT×1 GLUT4×1

Frequently Co-occurring Enzymes

Glycogen synthase×1 Glycogen phosphorylase×1 Branching enzyme×1 Debranching enzyme×1 Phosphorylase kinase×1 Protein phosphatase 1×1 Insulin receptor kinase×1 PI3K×1 AKT×1 GSK-3β×1 mTOR×1 PTP1B (negative regulator)×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Glycogen Metabolism

Synthesis and degradation of glycogen for glucose storage and release.

GlycogenUDP-glucoseGlucose-1-phosphate+5

Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6

Cross-Referenced

4

— connected via related pathways

Glycolysis

The breakdown of glucose into pyruvate, yielding ATP and NADH.

GlucoseGlucose-6-phosphateFructose-1,6-bisphosphate+4

Gluconeogenesis

Synthesis of glucose from non-carbohydrate precursors.

PyruvateOxaloacetatePhosphoenolpyruvate+4

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6