Home/IGF-1R kinase

Enzyme

1 pathway

IGF-1R kinase

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

GHRH×1 Somatostatin×1 Ghrelin×1 GH×1 GHR×1 IGF-1×1 IGF-1R×1 IGFBP1-6×1 STAT5×1

Frequently Co-occurring Enzymes

JAK2×1 STAT5a/5b×1 PI3K×1 AKT×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Growth Hormone / IGF-1 Axis

GH-driven somatic growth and metabolism via hepatic IGF-1 production.

GHRHSomatostatinGhrelin+6

Cross-Referenced

3

— connected via related pathways

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6