Home/mTORC1

Molecule

2 pathways

mTORC1

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

PIP2×1 PIP3×1 AKT/PKB×1 mTORC2×1 PTEN×1 PDK1×1 4E-BP1×1 S6K1×1 AMP×1 ADP×1 ATP×1 AMPK (α/β/γ subunits)×1

Frequently Co-occurring Enzymes

PI3K×1 AKT×1 mTOR×1 PTEN×1 PDK1×1 S6 kinase×1 AMPKα1/α2×1 LKB1×1 CaMKKβ×1 ACC1/2 (target)×1 ULK1 (target)×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Signal Transduction

AMPK Pathway

Cellular energy sensor activating catabolic and inhibiting anabolic pathways.

Cross-Referenced

4

— connected via related pathways

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6

Autophagy

Self-digestion pathway recycling cellular components via lysosomal degradation.

ULK1 complexBeclin-1VPS34+6