Home/JAK1/2/3, TYK2

Molecule

1 pathway

JAK1/2/3, TYK2

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

Cytokines (IL-6, IFN, EPO)×1 STAT1-6×1 SOCS1-7×1 PIAS×1

Frequently Co-occurring Enzymes

JAK1×1 JAK2×1 JAK3×1 TYK2×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Cross-Referenced

2

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4