Home/STAT3
Molecule & Enzyme
3 pathways

STAT3

Found in 3 curated pathways across 2 categories.

Interaction Network

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Active In Categories

developmentalendocrine

Frequently Co-occurring Molecules

Leptin×2LepRb×2JAK2×2SOCS3×2PTP1B×2POMC×2AgRP×2NPY×2α-MSH×2MC4R×2Oct4 (POU5F1)×1Sox2×1

Frequently Co-occurring Enzymes

JAK2×2PI3K×2AMPK (inhibited by leptin)×2SHP2×2JAK/STAT3×1GSK-3β×1MEK/ERK×1Polycomb (PRC2)×1Trithorax (MLL)×1

Cross-Referenced Pathways

3 direct · 7 cross-referenced · 10 shown

Cross-Referenced

7
— connected via related pathways
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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3
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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
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Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5
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Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2
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Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6
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Signal Transduction

AMPK Pathway

Cellular energy sensor activating catabolic and inhibiting anabolic pathways.

AMPADPATP+5
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Developmental

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5