Home/Polycomb (PRC2)

Enzyme

1 pathway

Polycomb (PRC2)

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

Oct4 (POU5F1)×1 Sox2×1 Nanog×1 Klf4×1 c-Myc×1 LIF×1 STAT3×1 β-Catenin×1 Activin/Nodal×1

Frequently Co-occurring Enzymes

JAK/STAT3×1 GSK-3β×1 MEK/ERK×1 Trithorax (MLL)×1

Cross-Referenced Pathways

1 direct · 4 cross-referenced · 5 shown

Direct Involvement

1

Stem Cell Pluripotency Network

Transcription factor network maintaining embryonic stem cell self-renewal.

Oct4 (POU5F1)Sox2Nanog+6

Cross-Referenced

4

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5