β-Catenin

Found in 2 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

signaling developmental

Frequently Co-occurring Molecules

Wnt ligands×1 Frizzled receptor×1 LRP5/6×1 APC×1 Axin×1 Dishevelled×1 TCF/LEF×1 Oct4 (POU5F1)×1 Sox2×1 Nanog×1 Klf4×1 c-Myc×1

Frequently Co-occurring Enzymes

GSK-3β×2 CK1α×1 Porcupine×1 Tankyrase×1 JAK/STAT3×1 MEK/ERK×1 Polycomb (PRC2)×1 Trithorax (MLL)×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

📡

Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5

🌱

Developmental

Stem Cell Pluripotency Network

Transcription factor network maintaining embryonic stem cell self-renewal.

Oct4 (POU5F1)Sox2Nanog+6

Cross-Referenced

— connected via related pathways

📡

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

📡

Signal Transduction

Notch Signaling Pathway

Juxtacrine signaling controlling cell fate decisions via proteolytic receptor activation.

Notch 1-4 receptorsDelta-like ligands (DLL1, DLL3, DLL4)Jagged ligands (JAG1, JAG2)+3

📡

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

🌱

Developmental

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.

SHHIHHDHH+4

🌱

Developmental

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5