Home/MDA5

Molecule

1 pathway

MDA5

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

IFN-α×1 IFN-β×1 IFNAR1/2×1 STAT1/STAT2×1 IRF9×1 ISGF3×1 RIG-I×1 cGAS×1 STING×1

Frequently Co-occurring Enzymes

cGAS×1 TBK1×1 JAK1×1 TYK2×1 PKR×1 RNase L×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Immune Response

Type I Interferon Response

Antiviral defense system activating hundreds of interferon-stimulated genes.

IFN-αIFN-βIFNAR1/2+7

Cross-Referenced

3

— connected via related pathways

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Toll-Like Receptor (TLR) Signaling

Pattern recognition receptors activating innate immune responses.

TLR1-10LPSCpG DNA+6