Home/Glycine

Molecule

2 pathways

Glycine

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Tetrahydrofolate (THF)×1 5-Methyl-THF×1 5,10-Methylene-THF×1 SAM×1 SAH×1 Homocysteine×1 Methionine×1 Serine×1 Succinyl-CoA×1 δ-Aminolevulinic acid (ALA)×1 Porphobilinogen×1 Uroporphyrinogen III×1

Frequently Co-occurring Enzymes

Dihydrofolate reductase (DHFR)×1 Thymidylate synthase×1 MTHFR×1 Methionine synthase (MS)×1 SHMT (serine hydroxymethyltransferase)×1 ALA synthase (ALAS1/2)×1 ALA dehydratase×1 Porphobilinogen deaminase×1 Uroporphyrinogen decarboxylase×1 Ferrochelatase×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Folate / One-Carbon Metabolism

Transfer of one-carbon units for nucleotide synthesis, methylation, and amino acid metabolism.

Tetrahydrofolate (THF)5-Methyl-THF5,10-Methylene-THF+6

Heme Biosynthesis

Eight-step pathway producing heme from glycine and succinyl-CoA.

GlycineSuccinyl-CoAδ-Aminolevulinic acid (ALA)+5

Cross-Referenced

4

— connected via related pathways

Citric Acid Cycle (Krebs Cycle)

Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.

Acetyl-CoACitrateIsocitrate+6

Amino Acid Catabolism

Degradation of amino acids to metabolic intermediates and ammonia.

Amino acidsα-KetoglutarateGlutamate+4

Nucleotide Biosynthesis

De novo and salvage pathways for purine and pyrimidine nucleotide production.

Genetic Information

Epigenetic Regulation

Heritable changes in gene expression without altering the DNA sequence.

5-MethylcytosineHistone H3/H4CpG islands+4